Emory University / Department of Environmental Sciences / 400 Dowman Dr. Atlanta, GA 30322 / 5th floor Suite E530 

In Mexico, we are enhancing passive surveillance systems by incorporating measures of adult Aedes aegypti infection as another proxy for transmission risk and a trigger for interventions. We have published an article showing the sensitivity of an entomo-virological surveillance in detecting dengue and Chikungunya infections inside houses (Dzul-Manzanilla et al. Trans. R. Soc. Trop. Med. Hyg. 110(2):141-144). More recently, this surveillance system (which relies on the use of Prokopack mosquito aspirators) has detected the first Zika virus infected Aedes albopictus of Mexico (paper under review). 

As part of the "Partnership for Dengue Control" we have developed a framework to evaluate the epidemiological impact of vector control on dengue, after accounting for the role of human mobility in separating risk of infection from place of residence. The article, led by Bobby Reiner, shows how randomized control trials (the gold standard for intervention evaluation) can be adapted to account for human movement. Findings were published in PLoS Negl. Trop. Dis. 10(5): e0004588). On the right, we show how can we calculate time under treatment, a key variable modulating the impact of a vector control intervention.

Improving vector control interventions

Centers for Disease Control and Prevention (CDC: OADS BAA 2016-N-17844)

This project will develop a ‘rapid’ approach for the delivery of indoor residual spraying by changing the equipment used and targeting indoor resting locations of Aedes aegypti.

USAID:AID‐OAA‐F‐16‐00094, Gregor Devine, QIMR, Australia, PI)

 

In 2017-19, we will begin a new project aiming to perform field trials in Merida, Mexico, evaluating the impact of metofluthrin passive emanators on Aedes aegypti biting behavior and abundance. 2017-2019.

In Mexico, we are evaluating the impact of two high-quality interventions: Indoor Residual Spraying and Insecticide Treated screens (i-Screens). We have published results of the positive entomologic impact of i-Screens on Aedes aegypti. This environmental management tool can have significant entomologic as well as quality of life impacts, which can trigger improvements in public health. Findings of our research were published by Manrique-Saide et al. Emerging Infectious Diseases, 21(2): 308-311, and Che-Mendoza et al. Transactions of the Royal Society of Tropical Medicine and Hygiene, 109: 106-115.)

In Cairns, Australia, we analyzed information from a recent dengue outbreak to quantify the metropolitan spread of the virus and, at the same time, quantify the impact of targeted indoor residual spraying (TIRS). We  capitalized on the use of spatial analysis to quantify the impact of TIRS in transmission chains that received the intervention versus chains that did not. We found that TIRS prevented 86% of future dengue cases (Vazquez-Prokopec et al. Science Advances 2017).

TIRS represents a promising tool for Aedes-borne disease prevention. We are currently performing randomized controlled trials evaluating their entomological efficacy. Additionally, and in collaboration with Dr Ira Longini (UFlorida) we are simulating TIRS deployment in Yucatan, Mexico.