Eco-evolutionary dynamics of insecticide resistance
National Science Foundation
The goal of this project is to understand the spatial and temporal dynamics of insecticide resistance as they relate to vector management regimes.
As insecticide-based interventions are deployed, there is need to understand how evolutionary processes impact the success of such efforts. Insecticide resistance has emerged as a major problem to public health, and there is a desperate need to understand the ecological determinants of the emergence and propagation of genes that confer resistance to high-quality insecticides. We provide evidence of a high spatial heterogeneity in the distribution of resistance alleles and phenotypes around the city of Merida, Mexico (Deming R et al. BMC Parasites and Vectors 9: 67.). A randomized controlled trial found that deltamethrin resistance significantly reduces the effectiveness of insecticide-based interventions (Vazquez-Prokopec et al. PLoS Negl. Trop. Dis. 2017).