Emory University / Department of Environmental Sciences / 400 Dowman Dr. Atlanta, GA 30322 / 5th floor Suite E530 

Eco-evolutionary dynamics of insecticide resistance

National Science Foundation

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The goal of this project is to understand the spatial and temporal dynamics of insecticide resistance as they relate to vector management regimes.

As insecticide-based interventions are deployed, there is need to understand how evolutionary processes impact the success of such efforts. Insecticide resistance has emerged as a major problem to public health, and there is a desperate need to understand the ecological determinants of the emergence and propagation of genes that confer resistance to high-quality insecticides. We provide evidence of a high spatial heterogeneity in the distribution of resistance alleles and phenotypes around the city of Merida, Mexico (Deming R et al. BMC Parasites and Vectors 9: 67.). A randomized controlled trial found that deltamethrin resistance significantly reduces the effectiveness of insecticide-based interventions (Vazquez-Prokopec et al. PLoS Negl. Trop. Dis. 2017).